Diabetes mellitus is a common worldwide metabolic disorder due to decreased physical activity, increased stress,\r\nobesity and change in food consumption pattern. It is characterized by chronic hyperglycemia, polyuria, polydipsia, polyphagia\r\nand weakness due to disturbance in carbohydrate, fat and protein metabolism and also associated with absolute or relative\r\ndeficiency in insulin secretion and/or insulin action. In 2004, according to the world health organization reports, more than 150\r\nmillion people throughout the world suffered from diabetes. Piper attenuatum (B. Ham.) can cure diabetes as mentioned in the\r\nliterature survey of traditional Indian system of medicine but not proved scientifically so the aim of the present study is to\r\ndetermine the effect of Piper attenuatum (B.Ham.) on diabetes. In our study we induce diabetes in 2 days old rats by using\r\nstreptozotocin. Ethanolic seed extract of plant was obtained by soxhlet extraction. The ethanolic extract contains active\r\nconstituent like piperine, piperlonguminine etc. It may be possible that piperine and piperlonguminine causes anti-diabetic\r\nactivity. Plant extract causes decrease in total serum glucose, cholesterol, triglycerides level, food and water intake and increase\r\nin body weight in different rat groups when compared to diabetic untreated groups. Histopathology is also carried out for\r\npancreas. The ethanolic extract of Plant showed significant results in anti-diabetic model. A dose of 200 mg/kg and 400 mg/kg\r\nwas used. Values are expressed as mean�±S.E.M. Glibenclamide (10 mg/kg) was used as standard drug. The total time period of\r\nthe study was 3 week
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